Rigapples, on 01 December 2012 - 07:24 PM, said:
As a Rogue (sin):
Pretty easy fight. Prepot - open with Cheap Shot if possible (if you aren't close enough when he spawns, he will hit you out of stealth.)
Pop Combat Readiness immediately and start your normal rotation:
Envenom to refresh SnD
At about 50% - Pop SB + Vendetta
5CP Kidney Shot
Burn him down. if Kidney is about to end and he's not dead yet, pop Evasion.
Should be an easy fight.
As a Rogue, I waited a bit before using Combat Readiness. At the beginning, Recuperate and Leeching Poison were enough to keep me at full health for half of the fight. Then, Mazhareen started hitting very hard (she hits harder as she loses health), so I started using Kidney Shot, Evasion, Combat Readiness, Cloak of Shadows (+ glyph) and then Preparation to reset the cooldown of Evasion and Cloak of Shadows.
Obviously, the better your gear is, the easier it gets, and the less you need to use defensive abilities.