Alchemist Guide for Diablo 4 (Season 3)

Introduction

The Alchemist is an important NPC throughout your adventures across Sanctuary. This guide covers the benefits of upgrading potions, crafting Elixirs, refining materials, or crafting Incense and consumables. Upgrading the character’s Healing Potions is very important, allowing you to improve the gameplay experience and progress further in the game. 

How to Unlock the Alchemist

Upon reaching Level 10, you will have to complete a priority quest leading you to visit Veroka, the Alchemist in Kyovashad. In order to complete the quest, Weak healing potions will have to be upgraded into Tiny Healing Potion, for the price of 8 Gallowvine.

Alchemists are located in any major city of each zone. They are indicated on the map by a mortar and pestle icon:

How to Upgrade Potions

As your character progresses, you have the ability to upgrade the Healing potion. Each upgrade enhances the Healing vial’s ability to restore a greater amount of Life when it is used.

Make sure to visit the Alchemist in each main town and check for any new available upgrades whenever the character reaches a new level milestone. You can check out our Diablo 4 zones overview to quickly see all main towns of each area.

Below are the various upgrades, along with their resource cost and the enhanced effects they provide:

Potion Type	Resources needed	Effect
Weak Healing Potion Level 1	Available directly at Level 1	Heals 17 Life instantly and 35% Life over 3 seconds.
Tiny Healing Potion Unlocks at Level 10	• 8 Gallowvine • 250 Gold	Heals 48 Life Instantly and 35% Life over 3 seconds.
Minor Healing Potion Unlocks at Level 20	• 15 Gallowvine • 5 Biteberry • 400 Gold	Heals 80 Life instantly and 35% Life over 3 seconds.
Light Healing Potion Unlocks at Level 30	• 20 Gallowvine • 10 Biteberry • 5 Crushed Beast Bones • 470 Gold	Heals 141 Life instantly and 35% Life over 3 seconds.
Moderate Healing Potion Unlocks at Level 45	• 20 Gallowvine • 12 Howler Moss • 5 Demon’s Heart • 900 Gold	Heals 255 Life instantly and 35% Life over 3 seconds.
Strong Healing Potion Unlocks at Level 60	• 27 Gallowvine • 15 Reddamine • 5 Paletongue • 1,700 Gold	Heals 378 Life instantly and 35% Life over 3 seconds.
Greater Healing Potion Unlocks at Level 70	• 36 Blightshade • 18 Lifesbane • 5 Grave Dust • 5 Angelbreath • 2,500 Gold	Heals 559 Life instantly and 35% Life over 3 seconds.
Major Healing Potion Unlocks at Level 80	• 27 ReddamineReddamine • 27 Biteberry • 27 Blightshade • 27 Lifesbane • 27 Howler Moss • 10 Angelbreath • 5 Fiend Rose • 5,000 Gold	Heals 827 Life instantly and 35% Life over 3 seconds.
Superior Healing Potion Unlocks at Level 90	• 36 Blightshade • 36 Howler Moss • 20 Demon’s Heart • 20 Grave Dust • 20 Angelbreath • 10 Fiend Rose • 10 Forgotten Soul • 12,500 Gold	Heals 1,274 Life instantly and 35% Life over 3 seconds.

Craft Elixirs

Alchemists have the ability to brew various Elixirs, offering an experience boost and a stat boost for a duration of 30 minutes. Each Elixir requires a specific amount of gold and materials to craft, as the Alchemists require compensation for their services. These Elixirs can prove particularly valuable during World Boss fights or challenging high-end content. 

As your character gains levels, it becomes possible to craft stronger versions of each Elixir, which provide greater bonuses. However, keep in mind that crafting these enhanced versions requires higher crafting costs.

Refine and Reduce Resources

At the Alchemist, you have the option to refine or reduce excess materials, which can be particularly useful when you possess an abundance of basic materials but require higher grade or rarer materials. The Alchemist is capable of transforming certain materials into higher-grade versions of the same type. For instance, it is possible to refine 10x Iron Chunk into a Silver Ore.

Additionally, you can use Biteberry (just as an example) or other basic resources to effectively decrease the quantity of a specific material. This process allows you to regain a larger amount of Gallowvine from the reduced material once again.

Below is a list of materials that can be obtained through refinement at the Alchemist:

Herbs

Herbs that are used to craft potions, elixirs, and incense:

Gallowvine
Can be found nearly everywhere.
Refined from different sources: 1 Biteberry or 1 Blightshade or 1 Howler Moss or 1 Lifesbane or 1 Reddamine, + 200 Gold.

Biteberry
Found in Fractured Peaks.
Refined from: 5 Gallowvine, 200 Gold.

Blightshade
Found in Hawezar.
Refined from: 5 Gallowvine, 200 Gold.

Howler Moss
Found in Scosglen.
Refined from: 5 Gallowvine, 200 Gold.

Lifesbane
Found in Kehjistan.
Refined from: 5 Gallowvine, 200 Gold.

Mushrooms

Fungus used to craft potions, elixirs, and incense:

Reddamine
Found in Dry Steppes.
Refined from: 5 Gallowvine, 200 Gold.

Metals

Rare metals used for improving weapons and jewelry:

Silver Ore
Found in veins nearly everywhere.
Refined from: 10 Iron Chunk, 200 Gold.

Leather

Rare leather used for improving armor:

Superior Leather
Can drop from various life forms over Sanctuary like wildlife and beasts.
Refined from: 5 Rawhide, 200 Gold.

Craft Incenses

Incenses function similarly to Elixirs, providing temporary bonuses to players. However, the key distinction is that incenses are particularly beneficial when you are part of a party, as the buffs they provide extend to the entire party. The first incense becomes available at Level 45, and only one incense can be active at a time.

Moreover, Incenses are categorized into different tiers known as types. It is important to remember that only one type of incense can be active simultaneously. However, this also creates an opportunity for players to use both a Type I, Type II and Type III Incense concurrently, as long as they are distinct types.

Below is a list of incenses and their respective bonuses:

Incense	Effect	Tier / Type	Materials needed to craft
Chorus of War, Requires Level 100	Increases all stats by 40 and Crit and Overpower Damage by 5% for every nearby player. Lasts 20 minutes.	Type III	• Biteberry x20 • Paletongue x10 • Demon’s Heart x10 • Grave Dust x10 • Crushed Beast Bones x10 • Fiend Rose x5 • 5,000 Gold
Spirit Dance, Requires Level 80	Increases Chance to Dodge by 5% for every nearby player. Lasts 20 minutes.	Type II	• Howler Moss x10 • Gallowvine x15 • Paletongue x5 • Angelbreath x5 • 5,000 Gold
Soothing Spices, Requires Level 75	Increases Resistance to All Elements by +10%, Maximum Resistance for All Elements by +1%, and Armor by 150 for every nearby player. Lasts 20 minutes.	Type II	• Howler Moss x30 • Lifesbane x30 • Angelbreath x5 • Fiend Rose x5 • Veiled Crystal x20 • Paletongue x5 • 5,000 Gold
Scents of the Desert Afternoon, Requires Level 70	Increases Thorns by 250 for every nearby player. Lasts 20 minutes.	Type II	• Howler Moss x12 • Reddamine x12 • Angelbreath x5 • Fiend Rose x2 • Veiled Crystal x5 • 5,000 Gold
Spiral Morning, Requires Level 65	Increases all stats by 15 for every nearby player. Lasts 20 minutes.	Type II	• Biteberry x12 • Blightshade x12 •Angelbreath x5 • Fiend Rose x2 • Lifesbane x12 • Howler Moss x12 • 5,000 Gold
Reddamine Buzz, Requires Level 60	Increases Maximum Life by 500 for every nearby player. Lasts 20 minutes.	Type II	• Reddamine x12 • Lifesbane x12 • Angelbreath x5 • Fiend Rose x2 • Grave Dust x5 • 5,000 Gold
Desert Escape, Requires Level 55	Increases Fire, Cold, and Shadow Resistances by +15% and their Maximum Resistances by +2% for every nearby player. Lasts 20 minutes.	Type I	• Lifesbane x10 • Blightshade x10 • Angelbreath x5 • Biteberry x10 • Demon’s Heart x5 • 5,000 Gold
Storm of the Wilds, Requires Level 55	Increases Lightning, Cold, and Poison Resistances by +15% and their Maximum Resistances by +2% for every nearby player. Lasts 20 minutes.	Type I	• Howler Moss x10 • Biteberry x10 • Angelbreath x5 • Reddamine x10 • Crushed Beast Bones x5 • 5,000 Gold
Ancient Times, Requires Level 50	Increases Strength by 25 for every nearby player. Lasts 20 minutes.	Type I	• Reddamine x10 • Blightshade x10 • Angelbreath x6 • Fiend Rose x2 • Demon’s Heart x5 • 5,000 Gold
Blessed Guide, Requires Level 50	Increases Willpower by 25 for every nearby player. Lasts 20 minutes.	Type I	• Biteberry x10 • Reddamine x10 • Angelbreath x5 • Fiend Rose x2 • Paletongue x5 • 5,000 Gold
Queen’s Supreme, Requires Level 50	Increases Dexterity by 25 for every nearby player. Lasts 20 minutes.	Type I	• Reddamine x10 • Lifesbane x10 • Angelbreath x5 • Fiend Rose x2 • Crushed Beast Bones x5 • 5,000 Gold
Sage’s Whisper, Requires Level 50	Increases Intelligence by 25 for every nearby player. Lasts 20 minutes.	Type I	• Howler Moss x10 • Blightshade x10 • Angelbreath x5 • Fiend Rose x2 • Grave Dust x5 • 5,000 Gold
Song of the Mountain, Requires Level 45	Increases Armor by 200 for every nearby player. Lasts 20 minutes.	Type I	• Biteberry x10 • Gallowvine x15 • Crushed Beast Bones x5 • Angelbreath x5 • 5,000 Gold

Craft Uber Uniques

With Patch 1.3.2, the Refine Resources tab was renamed “Transmute” and the option to craft Uber Uniques in exchange for 5 Resplendent Sparks was added. Resplendent Sparks can be obtained by salvaging other Uber Uniques.

Seasonal Mechanic

In Season 3, the Alchemist introduces a crafting option to create caches for summoning Varshan. You can access the crafting section in the Refine Resources tab, where you will need summoning materials and other components like Veiled Crystal, Abstruse Sigil, Baleful Fragment, and Coiling Ward to refine and craft the desired materials.