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Alchemist Guide for Diablo 4 (Season 3)

How to upgrade potions, craft elixirs, refine mats, and ignite incenses!

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Neviriah

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Introduction

The Alchemist is an important NPC throughout your adventures across Sanctuary. This guide covers the benefits of upgrading potions, crafting Elixirs, refining materials, or crafting Incense and consumables. Upgrading the character’s Healing Potions is very important, allowing you to improve the gameplay experience and progress further in the game. 

How to Unlock the Alchemist

Upon reaching Level 10, you will have to complete a priority quest leading you to visit Veroka, the Alchemist in Kyovashad. In order to complete the quest, Weak healing potions will have to be upgraded into Tiny Healing Potion, for the price of 8 GallowvineGallowvine.

Alchemist Potion Interface Diablo 4

Alchemists are located in any major city of each zone. They are indicated on the map by a mortar and pestle icon:

How to Upgrade Potions

As your character progresses, you have the ability to upgrade the Healing potion. Each upgrade enhances the Healing vial’s ability to restore a greater amount of Life when it is used.

Alchemy Potion Upgrade Diablo 4

Make sure to visit the Alchemist in each main town and check for any new available upgrades whenever the character reaches a new level milestone. You can check out our Diablo 4 zones overview to quickly see all main towns of each area.

Below are the various upgrades, along with their resource cost and the enhanced effects they provide:

Potion TypeResources neededEffect
Weak Healing Potion
Level 1
Available directly at Level 1Heals 17 Life instantly and 35% Life over 3 seconds.
Tiny Healing Potion
Unlocks at Level 10
• 8 GallowvineGallowvine
• 250 Gold
Heals 48 Life Instantly and 35% Life over 3 seconds.
Minor Healing Potion
Unlocks at Level 20
• 15 GallowvineGallowvine
• 5 BiteberryBiteberry
• 400 Gold
Heals 80 Life instantly and 35% Life over 3 seconds.
Light Healing Potion
Unlocks at Level 30
• 20 GallowvineGallowvine
• 10 BiteberryBiteberry
• 5 Crushed Beast BonesCrushed Beast Bones
• 470 Gold
Heals 141 Life instantly and 35% Life over 3 seconds.
Moderate Healing Potion
Unlocks at Level 45
• 20 GallowvineGallowvine
• 12 Howler MossHowler Moss
• 5 Demon's HeartDemon’s Heart
• 900 Gold
Heals 255 Life instantly and 35% Life over 3 seconds.
Strong Healing Potion
Unlocks at Level 60
• 27 GallowvineGallowvine
• 15 ReddamineReddamine
• 5 PaletonguePaletongue
• 1,700 Gold
Heals 378 Life instantly and 35% Life over 3 seconds.
Greater Healing Potion
Unlocks at Level 70
• 36 BlightshadeBlightshade
• 18 LifesbaneLifesbane
• 5 Grave DustGrave Dust
• 5 AngelbreathAngelbreath
• 2,500 Gold
Heals 559 Life instantly and 35% Life over 3 seconds.
Major Healing Potion
Unlocks at Level 80
• 27 ReddamineReddamineReddamine
• 27 BiteberryBiteberry
• 27 BlightshadeBlightshade
• 27 LifesbaneLifesbane
• 27 Howler MossHowler Moss
• 10 AngelbreathAngelbreath
• 5 Fiend RoseFiend Rose
• 5,000 Gold
Heals 827 Life instantly and 35% Life over 3 seconds.
Superior Healing Potion
Unlocks at Level 90
• 36 BlightshadeBlightshade
• 36 Howler MossHowler Moss
• 20 Demon's HeartDemon’s Heart
• 20 Grave DustGrave Dust
• 20 AngelbreathAngelbreath
• 10 Fiend RoseFiend Rose
• 10 Forgotten SoulForgotten Soul
• 12,500 Gold
Heals 1,274 Life instantly and 35% Life over 3 seconds.

Craft Elixirs

Alchemists have the ability to brew various Elixirs, offering an experience boost and a stat boost for a duration of 30 minutes. Each Elixir requires a specific amount of gold and materials to craft, as the Alchemists require compensation for their services. These Elixirs can prove particularly valuable during World Boss fights or challenging high-end content. 

Alchemist Elixir Interface Diablo 4

As your character gains levels, it becomes possible to craft stronger versions of each Elixir, which provide greater bonuses. However, keep in mind that crafting these enhanced versions requires higher crafting costs.

Refine and Reduce Resources

At the Alchemist, you have the option to refine or reduce excess materials, which can be particularly useful when you possess an abundance of basic materials but require higher grade or rarer materials. The Alchemist is capable of transforming certain materials into higher-grade versions of the same type. For instance, it is possible to refine 10x Iron ChunkIron Chunk into a Silver OreSilver Ore.

Additionally, you can use BiteberryBiteberry (just as an example) or other basic resources to effectively decrease the quantity of a specific material. This process allows you to regain a larger amount of GallowvineGallowvine from the reduced material once again.

Below is a list of materials that can be obtained through refinement at the Alchemist:

Herbs

Herbs that are used to craft potions, elixirs, and incense:

GallowvineGallowvine
Can be found nearly everywhere.
Refined from different sources: 1 Biteberry or 1 Blightshade or 1 Howler Moss or 1 Lifesbane or 1 Reddamine, + 200 Gold.

BiteberryBiteberry
Found in Fractured Peaks.
Refined from: 5 Gallowvine, 200 Gold.

BlightshadeBlightshade
Found in Hawezar.
Refined from: 5 Gallowvine, 200 Gold.

Howler MossHowler Moss
Found in Scosglen.
Refined from: 5 Gallowvine, 200 Gold.

LifesbaneLifesbane
Found in Kehjistan.
Refined from: 5 Gallowvine, 200 Gold.

Mushrooms

Fungus used to craft potions, elixirs, and incense:

ReddamineReddamine
Found in Dry Steppes.
Refined from: 5 Gallowvine, 200 Gold.

Metals

Rare metals used for improving weapons and jewelry:

Silver OreSilver Ore
Found in veins nearly everywhere.
Refined from: 10 Iron ChunkIron Chunk, 200 Gold.

Leather

Rare leather used for improving armor:

Superior LeatherSuperior Leather
Can drop from various life forms over Sanctuary like wildlife and beasts.
Refined from: 5 RawhideRawhide, 200 Gold.

Craft Incenses

Incenses function similarly to Elixirs, providing temporary bonuses to players. However, the key distinction is that incenses are particularly beneficial when you are part of a party, as the buffs they provide extend to the entire party. The first incense becomes available at Level 45, and only one incense can be active at a time.

Moreover, Incenses are categorized into different tiers known as types. It is important to remember that only one type of incense can be active simultaneously. However, this also creates an opportunity for players to use both a Type I, Type II and Type III Incense concurrently, as long as they are distinct types.

Below is a list of incenses and their respective bonuses:

IncenseEffectTier / TypeMaterials needed to craft
Chorus of WarChorus of War,
Requires Level 100
Increases all stats by 40 and Crit and Overpower Damage by 5% for every nearby player. Lasts 20 minutes.Type IIIBiteberryBiteberry x20
PaletonguePaletongue x10
Demon's HeartDemon’s Heart x10
Grave DustGrave Dust x10
Crushed Beast BonesCrushed Beast Bones x10
Fiend RoseFiend Rose x5
• 5,000 Gold
Spirit DanceSpirit Dance,
Requires Level 80
Increases Chance to Dodge by 5% for every nearby player. Lasts 20 minutes.Type IIHowler MossHowler Moss x10
GallowvineGallowvine x15
PaletonguePaletongue x5
AngelbreathAngelbreath x5
• 5,000 Gold
Soothing SpicesSoothing Spices,
Requires Level 75
Increases Resistance to All Elements by +10%, Maximum Resistance for All Elements by +1%, and Armor by 150 for every nearby player. Lasts 20 minutes.Type IIHowler MossHowler Moss x30
LifesbaneLifesbane x30
AngelbreathAngelbreath x5
Fiend RoseFiend Rose x5
Veiled CrystalVeiled Crystal x20
PaletonguePaletongue x5
• 5,000 Gold
Scents of the Desert AfternoonScents of the Desert Afternoon,
Requires Level 70
Increases Thorns by 250 for every nearby player. Lasts 20 minutes.Type IIHowler MossHowler Moss x12
ReddamineReddamine x12
AngelbreathAngelbreath x5
Fiend RoseFiend Rose x2
Veiled CrystalVeiled Crystal x5
• 5,000 Gold
Spiral MorningSpiral Morning,
Requires Level 65
Increases all stats by 15 for every nearby player. Lasts 20 minutes.Type IIBiteberryBiteberry x12
BlightshadeBlightshade x12
AngelbreathAngelbreath x5
Fiend RoseFiend Rose x2
LifesbaneLifesbane x12
Howler MossHowler Moss x12
• 5,000 Gold
Reddamine BuzzReddamine Buzz,
Requires Level 60
Increases Maximum Life by 500 for every nearby player. Lasts 20 minutes.Type IIReddamineReddamine x12
LifesbaneLifesbane x12
AngelbreathAngelbreath x5
Fiend RoseFiend Rose x2
Grave DustGrave Dust x5
• 5,000 Gold
Desert EscapeDesert Escape,
Requires Level 55
Increases Fire, Cold, and Shadow Resistances by +15% and their Maximum Resistances by +2% for every nearby player. Lasts 20 minutes.Type ILifesbaneLifesbane x10
BlightshadeBlightshade x10
AngelbreathAngelbreath x5
BiteberryBiteberry x10
Demon's HeartDemon’s Heart x5
• 5,000 Gold
Storm of the WildsStorm of the Wilds,
Requires Level 55
Increases Lightning, Cold, and Poison Resistances by +15% and their Maximum Resistances by +2% for every nearby player. Lasts 20 minutes.Type IHowler MossHowler Moss x10
BiteberryBiteberry x10
AngelbreathAngelbreath x5
ReddamineReddamine x10
Crushed Beast BonesCrushed Beast Bones x5
• 5,000 Gold
Ancient TimesAncient Times,
Requires Level 50
Increases Strength by 25 for every nearby player. Lasts 20 minutes.Type IReddamineReddamine x10
BlightshadeBlightshade x10
AngelbreathAngelbreath x6
Fiend RoseFiend Rose x2
Demon's HeartDemon’s Heart x5
• 5,000 Gold
Blessed GuideBlessed Guide,
Requires Level 50
Increases Willpower by 25 for every nearby player. Lasts 20 minutes.Type IBiteberryBiteberry x10
ReddamineReddamine x10
AngelbreathAngelbreath x5
Fiend RoseFiend Rose x2
PaletonguePaletongue x5
• 5,000 Gold
Queen's SupremeQueen’s Supreme,
Requires Level 50
Increases Dexterity by 25 for every nearby player. Lasts 20 minutes.Type IReddamineReddamine x10
LifesbaneLifesbane x10
AngelbreathAngelbreath x5
Fiend RoseFiend Rose x2
Crushed Beast BonesCrushed Beast Bones x5
• 5,000 Gold
Sage's WhisperSage’s Whisper,
Requires Level 50
Increases Intelligence by 25 for every nearby player. Lasts 20 minutes.Type IHowler MossHowler Moss x10
BlightshadeBlightshade x10
AngelbreathAngelbreath x5
Fiend RoseFiend Rose x2
Grave DustGrave Dust x5
• 5,000 Gold
Song of the MountainSong of the Mountain,
Requires Level 45
Increases Armor by 200 for every nearby player. Lasts 20 minutes.Type IBiteberryBiteberry x10
GallowvineGallowvine x15
Crushed Beast BonesCrushed Beast Bones x5
AngelbreathAngelbreath x5
• 5,000 Gold

Craft Uber Uniques

With Patch 1.3.2, the Refine Resources tab was renamed “Transmute” and the option to craft Uber Uniques in exchange for 5 Resplendent Sparks was added. Resplendent Sparks can be obtained by salvaging other Uber Uniques.

Seasonal Mechanic

In Season 3, the Alchemist introduces a crafting option to create caches for summoning Varshan. You can access the crafting section in the Refine Resources tab, where you will need summoning materials and other components like Veiled CrystalVeiled Crystal, Abstruse SigilAbstruse Sigil, Baleful FragmentBaleful Fragment, and Coiling WardCoiling Ward to refine and craft the desired materials.

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