Introduction
Mythic Uniques are the rarest and most powerful items in Diablo 4. They have unique effects that can drastically change your build and gameplay. However, Mythic Uniques are extremely hard to find and only have around a 2% chance to drop from farming endgame or greater and exalted lair bosses. For example, Duriel, Andariel, and the Harbinger of Hatred have a higher chance of dropping Mythic Uniques than any other boss in the game.
Additionally, Belial, the Exalted Lair Boss, can also be an interesting boss to farm for Mythic Uniques, as Belial allows you to pick a loot pool to target. If you defeat Belial, you can pick Duriel, Andariel, or the Harbinger of Hatred loot as reward when opening the chest. Belial has the highest chance of dropping Mythic Unique items.
Greater Lair Bosses are some of the most challenging but rewarding bosses in Diablo 4. To fight them, you need to reach a decent level and access Torment difficulty. Additionally, you also have to collect the necessary materials in order to open their treasure chests. Once all the requirements are met, you can farm these bosses for a chance of getting one or more Mythic Uniques.
Requirements and Preparation
If you want to obtain Mythic Uniques through killing bosses, keep in mind that they have a higher chance of dropping from Duriel the King of Maggots, Andariel the Maiden of Anguish, and the Harbinger of Death. However, Greater Lair Bosses can not be summoned in any World Tier lower than Torment difficulty. To access their Hoard after defeating them, you will need to farm the following materials.
Required Lair Boss Keys for their Hoard:
| Lair Boss | Required Lair Boss Keys | Drops from |
|---|---|---|
| Duriel | 3x  Shard of Agony | Grigoire or Varshan |
| Andariel | 3x  Pincushioned Doll | Lord Zir or The Beast in the Ice |
| Harbinger of Death (Vessel of Hatred) | 3x  Abhorrent Heart | Urivar (Vessel of Hatred) |
| Belial | 2x  Betrayer’s Husk | Belial’s Ambush |
Every Lair Boss requires a key to unlock their loot, including the Initiate Lair Bosses, such as Grigoire, Varshan, Lord Zir, The Beast in The Ice, or Urivar. To farm the needed materials for the Greater Lair Bosses, you will need to farm the materials needed for the Initiate Bosses as well. Check out our guide below.
Lair Boss System GuideHere is a quick overview of where to get each material:
| Material | Drops from |
|---|---|
 Malignant Heart | Whispers or Open World drops in Helltides |
 Living Steel | Helltides Chests |
 Distilled Fear | Nightmare Dungeons |
 Exquisite Blood | Elites in Legion Events, Helltides and World Bosses |
 Judicator’s Mask | Open World activities: Helltides, Whispers and World Bosses |
| Shard of Agony | Varshan or Grigoire |
| Pincushioned Doll | Lord Zir or Beast in the Ice |
| Abhorrent Heart | Urivar |
| Betrayer’s Husk | Belial’s Ambush |
Where and How to Summon
Once you have farmed the required materials, you can head to the dungeon of the Greater Lair Boss you want to defeat. Clear the dungeon and find the altar room. You can use the altar to summon the boss. Materials (keys) will only be used upon looting the Hoard after you defeat the Lair Boss.
It is advised to run these farming sessions in Torment 4 and as a group of 4, since every member in the group increases the chance of an additional Unique dropping as a reward. In Torment 4, the boss will drop a minimum of 7 Uniques.
Duriel:
Where: Gaping Crevasse in Kehjistan
Materials: 3x Shard of Agony (drops from Varshan or Grigoire)
Andariel:
Where: Hanged Man’s Hall in Kehjistan
Materials: 3x Pincushioned Doll (drops from Lord Zir or The Beast in the Ice)
Harbinger of Hatred:
Requirement: Vessel of Hatred Expansion
Where: Harbinger’s Den in Nahantu
Materials: 3x Abhorrent Heart (drops from Urivar)
Belial:
Where: Palace of the Deceiver in Kehjistan
Materials: 2x Betrayer’s Husk (drops from Belial’s Ambush)
Mythic Uniques
Once the Lair Boss is defeated, you will have a higher chance of getting one of the following Mythic Uniques as a reward:
Ahavarion, Spear of Lycander (Druid, Sorcerer)
Doombringer (Barbarian, Necromancer, Rogue)
The Grandfather (Barbarian, Necromancer)
Nesēkēm, the Herald (Spiritborn)
Harlequin Crest (All Classes)
Andariel’s Visage (All Classes)
Tyrael’s Might (All Classes) 
Ring of Starless Skies (All Classes)
Melted Heart of Selig (All Classes)
Furthermore, Initiate Lair Bosses have a small chance of dropping Mythic Uniques.
Crafting Mythic Uniques
Through the use of 
Resplendent Spark, players can craft a Mythic Unique they want. Here is how it works:
After you have spent some time target farming Duriel, Andariel, or the Harbinger of Hatred, and collected a number of unwanted or duplicate Mythic Uniques, you can salvage them to obtain a new material called Resplendent Spark, which can be used to create the Mythic Unique you want.
When salvaging any Mythic Unique, you will get 1 Resplendent Spark. Once you have collected 2 of those sparks, head to the Blacksmith and craft a Mythic Unique Cache with 2 Resplendent Spark to create a random Mythic Unique.
With Vessel of Hatred, the Jeweler Rune Crafting tab offers the option to craft Mythic Uniques in exchange for 2 Resplendent Spark and 3x 6 different Legendary Runes.
In addition, the chances of dropping Mythic Uniques have increased. If you are bored with farming Greater Bosses, other methods (Whisper Caches, Nightmare Dungeons, etc.) are now more likely to drop Mythic Uniques. Good luck!
Summary
Mythic Uniques are very powerful items that can drastically alter a build or playstyle. They can be extremely challenging to find, but through target farming or killing Greater or Exalted Bosses, you have a higher chance of getting your hands on one of them!
Make sure to team up with other players in order to maximize your farming time and materials. May the loot be in your favor!
