How to Farm Uniques from Bosses in Diablo 4 (Season 10)

In Diablo 4, players can target farm Uniques, including Mythic Uniques, by defeating specific Lair Bosses. Below, we will cover which bosses drop which Uniques and how to spawn them. You will also find details on cosmetic rewards and links to dedicated guides for each Lair Boss.

Lair Bosses

Lair Bosses are the best way to farm Uniques efficiently. You can fight them from Torment 1 to 4, with higher difficulties offering better chances for Ancestral Uniques. Keep in mind that Duriel, Andariel, and the Harbinger of Hatred have twice the drop rate for Mythic Uniques compared to other Lair Bosses. Belial guarantees an Ancestral Unique drop in his loot, and has the highest Mythic Unique drop chance of all Lair Bosses.

Grigoire, The Galvanic Saint

Where: Hall of Penitent in Dry Steppes
Materials: 12xLiving Steel (gathered in Helltides, by opening Tortured Offerings)
Cosmetics: Demonbinder Mount Armor (account bound)

All Classes: Penitent Greaves Endurant Faith	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Twin Strikes Rage of Harrogath Battle Trance The Butcher’s Cleaver Unbroken Chain The Grandfather Doombringer	Druid: Earthbreaker Insatiable Fury Hunter’s Zenith Waxing Gibbous The Butcher’s Cleaver Ahavarion, Spear of Lycander Doombringer	Necromancer: Ebonpiercer Howl from Below Greaves of the Empty Tomb The Butcher’s Cleaver Path of Trag’Oul The Mortacrux The Grandfather Doombringer
Rogue: Saboteur’s Signet Word of Hakan Grasp of Shadow Shroud of Khanduras Bands of Ichorous Rose Doombringer	Sorcerer: Flameweaver Staff of Lam Esen Iceheart Brais Axial Conduit Hail of Verglas Ahavarion, Spear of Lycander Doombringer	Spiritborn: Hesha e Kesungi Protection of the Prime Peacemonger’s Signet Ring of the Midnight Sun Loyalty’s Mantle Nesekem, the Herald

Demonbinder Mount Armor:

The Beast in the Ice

Where: Glacial Fissure in Fractured Peaks
Materials: 12x Distilled Fear (gathered in Nightmare Dungeons)
Cosmetics: The Skull Torch and Fell Steed Mount Trophies (account bound)

All Classes: Fists of Fate Tassets of the Dawning Sky Paingorger’s Gauntlets	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Ancients’ Oath Hellhammer Ring of the Ravenous Mantle of Mountain’s Fury Hooves of the Mountain God The Grandfather Doombringer	Druid: Storm’s Companion Unsung Ascetic’s Wraps Stone of Vehemen Gathlen’s Birthright Kilt of Blackwing Ahavarion, Spear of Lycander Doombringer	Necromancer: Ring of Mendeln Mutilator Plate The Unmaker Indira’s Memory The Grandfather Doombringer
Rogue: Windforce Eaglehorn Beastfall Boots Deathmask of Nirmitruq Doombringer	Sorcerer: Gloves of the Illuminator The Oculus Starfall Coronet Strike of Stormhorn Ahavarion, Spear of Lycander Doombringer	Spiritborn: Harmony of Ebewaka Scorn of the Earth Ring of the Midday Hunt Wound Drinker Nesekem, the Herald

The Skull Torch and Fell Steed Mount Trophies:

Varshan

Where: Malignant Burrow in Hawezar (near the Tree of Whispers)
Materials: 12x Malignant Heart (gathered by completing Whispers and as random drop in Helltides)
Cosmetics: Flesh-weld Rod Mount Trophy (account bound)

All Classes: Frostburn Mother’s Embrace Shard of Verathiel (besides Spiritborn) Rakanoth’s Wake	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Fields of Crimson 100,000 Steps Gohr’s Devastating Grips Ring of Red Furor Sabre of Tsasgal The Grandfather Doombringer	Druid: Mad Wolf’s Glee Vasily’s Prayer Greatstaff of the Crone Airidah’s Inexorable Will Rotting Lightbringer Ahavarion, Spear of Lycander Doombringer	Necromancer: Bloodless Scream Deathless Visage Deathspeaker’s Pendant Ring of the Sacrilegious Soul Gospel of the Devotee The Grandfather Doombringer
Rogue: Condemnation Eyes in the Dark Skyhunter Writhing Band of Trickery Doombringer	Sorcerer: Staff of Endless Rage Esu’s Heirloom Raiment of the Infinite Tal Rasha’s Iridescent Loop Ahavarion, Spear of Lycander Doombringer	Spiritborn: Craze of the Dead God Ring of Writhing Moon Sunstained War-Crozier Balazan’s Maxtlatl Nesekem, the Herald

Flesh-weld Rod Mount Trophy:

Lord Zir

Where: The Darkened Way in Fractured Peaks
Materials: 12x Exquisite Blood (gathered by completing Legion Events or killing World Bosses)
Cosmetics: The Diadem of the Ancient Helm (account bound)

All Classes: Razorplate Temerity Yen’s Blessing	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Arreat’s Bearing Ramaladni’s Magnum Opus Overkill Ugly Bastard Helm The Grandfather Doombringer	Druid: Wildheart Hunger Fleshrender Mjölnic Ryng Malefic Crescent Ahavarion, Spear of Lycander Doombringer	Necromancer: Cruor’s Embrace Blood Artisan’s Cuirass Lidless Wall Kessime’s Legacy Sanguivor, Blade of Zir The Grandfather Doombringer
Rogue: Orphan Maker Scoundrel’s Kiss Asheara’s Khanjar Pitfighter’s Gull Assassin’s Stride Doombringer	Sorcerer: Fractured Winterglass Esadora’s Overflowing Cameo Sidhe Bindings Vox Omnium Okun’s Catalyst Ahavarion, Spear of Lycander Doombringer	Spiritborn: Wushe Nak Pa Band of First Breath Jacinth Shell Nesekem, the Herald

The Diadem of the Ancient Helm:

Urivar

Requirement: Vessel of Hatred Expansion
Where: Fields of Judgement in Nahantu
Materials: 12x Judicator’s Mask (gathered by completing Whispers and as random drop in Helltides or killing World Bosses)

All Classes: Paingorger’s Gauntlets Frostburn	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Hooves of the Mountain God Bane of Ahjad-Den Overkill Twin Strikes 100,000 Steps Ring of the Ravenous Unbroken Chain Rage of Harrogath The Grandfather Doombringer	Druid: Gathlen’s Birthright Rotting Lightbringer Ahavarion, Spear of Lycander Doombringer	Necromancer: Bloodless Scream Ebonpiercer Gospel of the Devotee The Grandfather Doombringer
Rogue: Bands of Ichorous Rose Deathmask of Nirmitruq Doombringer	Sorcerer: Hail of Verglas Ahavarion, Spear of Lycander Doombringer	Spiritborn: Balazan’s Maxtlatl Hesha e Kesungi Nesekem, the Herald

Greater and Exalted Lair Bosses: Duriel, Andariel, Harbinger of Hatred, and Belial

For a more detailed page on how to farm Mythic Uniques, check out our dedicated guide:

Duriel

Where: Gaping Crevasse in Kehjistan
Materials: 3x Shard of Agony (drops from Varshan or Grigoire)
Cosmetics: Smouldering Brimstone Mount (account bound)

All Classes: Azurewrath Crown of Lucion Godslayer Crown X’Fal’s Corroded Signet Soulbrand Banished Lord’s Talisman	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Tuskhelm of Joritz the Mighty The Third Blade The Grandfather Doombringer	Druid: Tempest Roar Dolmen Stone Ahavarion, Spear of Lycander Doombringer	Necromancer: Blood Moon Breeches The Hand of Naz The Grandfather Doombringer
Rogue: Cowl of the Nameless Scoundrel’s Leathers Doombringer	Sorcerer: Blue Rose Ophidian Iris Ahavarion, Spear of Lycander Doombringer	Spiritborn: Rod of Kepeleke Sepazontec Nesekem, the Herald

Andariel

Where: Hanged Man’s Hall in Kehjistan
Materials: 3x Pincushioned Doll (drops from Lord Zir or The Beast in the Ice)
Cosmetics: Smouldering Brimstone Mount (account bound)

All Classes: Azurewrath Flickerstep Locran’s Talisman Tibault’s Will X’Fal’s Corroded Signet Soulbrand	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Tuskhelm of Joritz the Mighty Bane of Ahjad-Den The Grandfather Doombringer	Druid: Dolmen Stone The Basilisk Ahavarion, Spear of Lycander Doombringer	Necromancer: Black River Blood Moon Breeches The Grandfather Doombringer
Rogue: Cowl of the Nameless The Umbracrux Doombringer	Sorcerer: Flamescar Galvanic Azurite Blue Rose Ahavarion, Spear of Lycander Doombringer	Spiritborn: Sepazontec Sunbird’s Gorget Nesekem, the Herald

Harbinger of Hatred

Requirement: Vessel of Hatred Expansion
Where: Harbinger’s Den in Nahantu
Materials: 3x Abhorrent Heart (drops from Urivar)

All Classes: Godslayer Crown Crown of Lucion Flickerstep Locran’s Talisman Tibault’s Will Banished Lord’s Talisman	Mythic Uniques: Melted Heart of Selig Andariel’s Visage Harlequin Crest Ring of Starless Skies	Tyrael’s Might Heir of Perdition Shroud of False Death Shattered Vow
Barbarian: Bane of Ahjad-Den The Third Blade The Grandfather Doombringer	Druid: Tempest Roar The Basilisk Ahavarion, Spear of Lycander Doombringer	Necromancer: Black River The Hand of Naz The Grandfather Doombringer
Rogue: Scoundrel’s Leathers The Umbracrux Doombringer	Sorcerer: Flamescar Galvanic Azurite Ophidian Iris Ahavarion, Spear of Lycander Doombringer	Spiritborn: Rod of Kepeleke Sunbird’s Gorget Nesekem, the Herald

Belial

Where: Palace of the Deceiver in Kehjistan
Materials: 2x Betrayer’s Husk (drops from Belial’s Ambush)
Belial’s loot is unique as you can decide which boss’ loot pool to target before opening the chest.

Smouldering Brimstone Mount:

Good luck farming your Uniques! Before taking on Lair Bosses, make sure to check which Uniques are best for your build so you can target the right bosses.