Experiment

Sub Rogue - Glyph of Hemorrhaging Veins - Question

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You cannot skip Rupture. Sanguinary Vein not only boosts overall damage when active, it boosts Rupture damage, making it a preferred finisher over Eviscerate (if you aren't clipping the debuff). The only time you skip Rupture on a target is when you've already applied Sanguinary Vein using that glyph and the target will die before Rupture finishes ticking. The guide mentions not applying Rupture while Garrote is active during your opener, and that is to take advantage of all your buffs being active at once to give you huge Eviscerate hits.

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Just to expand on what Krush said:

 

The reason you don't skip Rupture is that it has better damage per energy compared to Eviscerate. It's worth applying Rupture if it will last around half it's duration - that's where it breaks even in damage dealt with Evis

 

In any case, this all changes with WoD when BS and Amb multistrikes cause Rupture to tick down and deal damage instantly, so you'll want to refresh asap in order to keep the bleed up and avoid needing to reapply it during Find Weakness

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Am i wrong when i say that in WoD you will have to use way more Ruptures than Evis'es ?

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It is true we will be casting it more due to the new Sinister Calling advancing our bleeds. Whether it is "way more" is unsure. I'm foreseeing a lot more care and energy/point pooling at low Rupture levels though, because we won't be able to guarantee that we can work our way back up to 5 combo points as the timer lurches randomly downwards. This will also be the case because we'll be we'll be able to refresh Rupture without repercussion at sub 7 seconds.

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