Annihilation Simulacrum Guide and Best Agents for Zenless Zone Zero
Annihilation Simulacrum is an Endgame mode in Zenless Zone Zero where you have to face three different bosses with trial characters instead of your own. Fight bosses with unique mechanics, learn the best teams for Annihilation Simulacrum, and claim all the rewards!
What is Annihilation Simulacrum in Zenless Zone Zero?
Annihilation Simulacrum is a high-stakes endgame challenge mode in Zenless Zone Zero, designed around fighting bosses with specific mechanics, and more importantly, using trial characters.
Annihilation Simulacrum does not allow players to use their personally-built characters. Instead, the game mode provides a finite roster of characters for the Extreme mode difficulty.
The Annihilation Simulacrum challenge period resets every patch, providing new bosses, new rewards, and a new roster of trial characters.
Annihilation Simulacrum Available Difficulties
Annihilation Simulacrum features two difficulty levels:
- Standard Mode
- Extreme Mode
Standard mode is similar to standard boss fights in Zenless Zone Zero. Meanwhile, Extreme Mode increases the boss difficulty by inflating the HP pool and provides an overall tougher experience.
Furthermore, Standard mode provides the bulk of rewards available in Annihilation Simulacrum, as all Polychrome rewards are available to claim from completing this mode.
Annihilation Simulacrum Stage Guide and Best Teams
Integrated - Haytor Guide
| Special Challenge |
|---|
| Sucessfully defeat 1 Clone of Integrated - Haytor. |
| Stage Overview |
| During combat, the Boss will alternate between two enhanced states: "Frenzy" and "Phantom." When the Boss's Daze accumulates to a certain level, it will summon Clones, during which Daze cannot be accumulated. Agents must defeat its Clones within a time limit - each Clone defeated accumulates the Boss's Daze and greatly increases its Stun DMG Multiplier and the Sheer DMG it recieves. If all Clones are not eliminated in time, the Boss will absorb the remaining Clones and resume its offensive. If Agents take no damage and use a Chain Parry to counter a Clone's High-Risk attack, a Shutdown can be triggered, additionally reducing the Clone's HP and Miasmic Shield. |
Best Teams
Extreme Mode
Standard Mode
Fight Advice
Hayoto's summoned clones are the priority in this fight, as defeating them inflicts large amounts of Daze and increases the STUN DMG multiplier on the boss. The best way to deal with them effectively is to use as many Chain Parries as possible to trigger Shutdown. Shutdown does a signficant amount of damage and is worth hyperfocusing on to deal with this boss. The Clones must be handled carefully to succeed.
Integrated - Infernal Revenant Guide
| Special Challenge |
|---|
| Inflict Snapfreeze on Integrated - Infernal Revenant 4 times. |
| Stage Overview |
| When the Boss enters combat, it will have a Molten Crystal Barrier. When an Agent triggers a Defensive Assist or Dodge Counter, or inflicts an Ice Attribute Anomaly on the Boss, the Boss's Molten Crystal Barrier will be reduced.hen the Molten Crystal Barrier is fully depleted, the Boss will immediately enter a Stunned state. During combat, pressing the Special Attack button will put the current Agent into the Subzero Barrier state for 0.5 seconds. While Subzero Barrier is active, receiving a red-light attack from the Boss will Negate that attack and reduce the Boss's Molten Crystal Barrier. If the Boss is currently under the Burn anomaly state, it will additionally deal DMG based on Max HP. While the Boss is Stunned, pressing the Special Attack button will inflict the Snapfreeze effect on the Boss, dealing DMG based on max HP. After an Agent triggers an Attribute Anomaly, the Special Attack button's cooldown will be additionally refreshed. |
Best Teams
Extreme Mode
Standard Mode
Fight Advice
Infernal Revenant has a special shield called Molten Crystal Barrier that must be broken using the Subzero Barrier button when the boss flashes red. Doing so will parry the red attack and greatly reduce the barrier. To win this fight effeicently, making certain to parry each and every red attack with Subzero Barrier is paramount. When Molten Crystal Barrier is depleted, the boss will become instantly stunned.
While Infernal Revevant is in the stunned state, press the Snapefreeze button to deal massive amounts of damage to it. Snapfreeze has a cooldown, but it can be reduced by triggering Attribute Anomalies on the boss.
Integrated - Sacrifice - Heretic Jester
| Special Challenge |
|---|
| Stun Integrated - Sacrifice - Heretic Jester within 60 seconds. |
| Stage Overview |
| During combat, the boss will summon Reward Magic Box, Trap Magic Box, and Frenzy Magic Boss. When an Agent triggers the Reward Magic Box, the Boss will not launch any attacks, and all Agents on the whole squad will receive Energy, Adrenaline, Sharpness, and Decibels every second. When an Agent triggers the Trap Magic Box, the Boss will launch attacks, and parrying all of the Boss's attacks will accumulate 50% Daze. When an Agent triggers the Frenzy Magic Box, the Boss will activate its Miasmic Shield and launch a fierce series of attacks. Parry all of the Boss's attacks to Break the Miasmic Shield and make it Stunned. Whenever all attacks following a Frenzy Magic Box trigger are successfully parried, the Boss's DEF is reduced by 30% and the whole squad's Agents gain a 30% CRIT DMG increase for 20 seconds;repeated triggers reset the duration. Whenever 2 attacks following a Trap Magic Box trigger are successfully parried, the Boss's DEF is reduced by 15% and the whole squad's Agents gain a 15% CRIT DMG increase for 20 seconds; repeated triggers reset the duration. After the boss recovers from the Stun, it will hurl several throwing knives into the air; parrying all throwing knives will accumulate a large amount of Daze. |
Best Teams
Extreme Mode
Standard Mode
Fight Advice
Jester summons a number of Magic Boxes on the field that can be interacted with. While there are a few ways to clear, we recommand focusing on the Trap and Frenzy boxes, to deal as much Daze damage on the boss as possible. This is the best way to clear the special condition of this stage.
Keep in mind that opening a Frenzy box will causing Jester to get a Miasmic Shield, so avoid doing so if the boss is close to being stunned. An accidental trigger could be disastrous for your clear time.
What are the Annihilation Simulacrum Rewards?
Annihilation Simulacrum provides rewards depending if you complete the mode's objectives, clearing on a specific difficulty, and clearing within a specific time frame.
Each fight rewards players with:
| Objective | Rewards |
|---|---|
| Complete fight-specific mechanic | Polychrome x40 Denny x20,000 |
| Clear Standard difficulty | Polychrome x80 Denny x20,000 |
| Clear Standard difficulty within 180s | Polychrome x40 Original Chip x3 |
| Clear Extreme difficulty within 180s | Hi-Fi Master Copy x9 Original Chip x3 |
Additionally, completing all missions for Standard Mode provides an extra 100 Polychromes.
The overall reward total per patch is:
- Polychrome x580
- Denny x120,000
- Original Chip x18
- Hi-Fi Master Copy x27
Annihilation Simulacrum rewards are refreshed each time the phase resets!
Changelog
- 25 Oct. 2026: Updated Encounter List for Version 3.3.
- 18 Jun. 2026: Adjusted table formatting and wording.
- 17 Jun. 2026: Annihilation Simulacrum Guide added.
More Zenless Zone Zero Guides
More Zenless Zone Zero Guides
Darrus Myles is a Narrative Designer and games writer specializing in RPGs, live-service games, and gameplay systems. A longtime HoYoverse fan, he spends most of his time in Zenless Zone Zero while keeping up with Honkai: Star Rail, though he'll never pass up an excuse to revisit Elden Ring or Baldur's Gate 3.
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