Ana Talents

Last updated on Apr 22, 2020 at 18:00 by Elitesparkle 39 comments
General Information

Welcome to our Talents page for Ana. Here, we give you an overview of how strong each of Ana's talents is. Then, we present several viable builds, before analyzing each talent row separately, so that you can make informed decisions.


Ana's Talent Build

Level Choices
1 Contact Healing ? Slumber Shells Vampiric Rounds
4 Biotic Enhancements Overdose ? Debilitating Dart
7 Anti-Healer Night Terrors Mind-Numbing Agent ?
10 Nano Boost Eye of Horus ?
13 Speed Serum Purifying Darts ? Smelling Salts
16 Sharpshooter Concentrated Doses Active Reload
20 Nano Infusion Deadeye ? Armored Stance ? Dynamic Optics ?

Ana's Talent Build Cheatsheet

Sleep Dart Build

Level 1 Slumber Shells Icon
Level 4 Debilitating Dart Icon
Level 7 Night Terrors Icon
Level 10 Nano Boost Icon
Level 13 Smelling Salts Icon Purifying Darts Icon ?
Level 16 Active Reload Icon
Level 20 Nano Infusion Icon

Ana's Sleep Dart Build is designed to compensate the Slow provided by the Aim Down Sights effect included in Shrike Icon Shrike by giving Ana some Movement Speed and by Slowing enemy Heroes with Slumber Shells Icon Slumber Shells and Night Terrors Icon Night Terrors respectively; furthermore, the latter Talent adds burst damage in the form of Percent Damage.


Level 1 Talents for Ana

Ana Contact Healing ?
Contact Healing (Level 1) Ana

Biotic Grenade heals for 30% more per allied and enemy Hero hit.

Ana Slumber Shells
Slumber Shells (Level 1) Ana

Reduce the cooldown of Sleep Dart by 4 seconds. Upon waking, enemy Heroes are Slowed by 25% for 3 seconds.

Ana Vampiric Rounds
Vampiric Rounds (Level 1) Ana

Quest: Stack 5 Doses on an enemy Hero or Basic Attack a Hero with 5 Doses.

Reward: Stack 5 Doses to increase Shrike's healing by 0.25%.

Reward: Basic Attack a Hero with 5 Doses to increase Shrike's healing by 0.25%.



Contact Healing Icon Contact Healing is a good Talent during team fights with several Heroes—regardless of friend or foe—clumping next to each other, but it is mostly used as a survivability tool against dives.

Slumber Shells Icon Slumber Shells is strong because it provides Ana a form of self-peeling while also increasing her Sleep Dart Icon Sleep Dart uptime, something that gets a good amount of value when combined with Night Terrors Icon Night Terrors at Level 7. Remember that reducing the cooldown of a Basic Ability makes you spend more Mana overall and that you should not go for such a Talent when you would prefer to hold the Ability for a better moment and/or for keeping your Mana.

Vampiric Rounds Icon Vampiric Rounds provides self-sustain tied to Basic Attacks. We do not recommend this Talent because you can increase your own survivability by going for Contact Healing Icon Contact Healing instead, a Talent that does not require you to unnecessarily expose to farm a Quest that is supposed to make you a bit harder to kill.


Level 4 Talents for Ana

Ana Biotic Enhancements
Biotic Enhancements (Level 4) Ana

Increase the bonus healing duration of Biotic Grenade by 50% and reduce its cooldown by 2 seconds.

Ana Overdose ?
Overdose (Level 4) Ana

Sleep Dart applies 4 Doses. While Aim Down Sights is active, Sleep Dart pierces all enemy Heroes.

Ana Debilitating Dart
Debilitating Dart (Level 4) Ana
  • Cooldown: 20 seconds

Activate to fire a dart which Slows the Movement Speed and reduces the damage dealt by the first enemy Hero it hits by 50% for 4 seconds.



Biotic Enhancements Icon Biotic Enhancements causes Biotic Grenade Icon Biotic Grenade to have a slightly lower cooldown and a bit higher uptime on the healing increase effect. The reduced cooldown is really low and it is also not really useful considering that you mostly want to hold Biotic Grenade for the perfect moment in order to reduce as much enemy healing as possible or to save an allied Hero who is suddenly in trouble. The increased bonus healing duration works only when you use Biotic Grenade in a defensive way and perfectly time it to empower an additional Healing Dart Icon Healing Dart than usual.

Overdose Icon Overdose could be useful in niche scenarios when you need additional pierce on Sleep Dart Icon Sleep Dart (for example when you want to interrupt Holy Word: Salvation Icon Holy Word: Salvation even if more than one enemy Hero is between Ana and Anduin), but we do not recommend this Talent anyways. The self-sustain provided is not that good compared to the benefits provided by Debilitating Dart Icon Debilitating Dart.

Debilitating Dart Icon Debilitating Dart is a strong Talent that gives Ana what she needs the most: self-peeling. This additional Active Ability can be used either before or after Sleep Dart Icon Sleep Dart. When you want to increase your chance to connect Sleep Dart, try hitting the enemy Hero with Debilitating Dart first because the Slow provided will help with that. When you want to be sure that Debilitating Dart will hit, use Sleep Dart first because the Sleep will make it impossible to miss. In short, use first what you need less and, whether you hit or miss, follow-up with what you need more.


Level 7 Talents for Ana

Ana Anti-Healer
Anti-Healer (Level 7) Ana

Increase the area of Biotic Grenade by 25% and the duration of the healing reduction by 25%.

Ana Night Terrors
Night Terrors (Level 7) Ana

Gain 25% Movement Speed for 2 seconds for every Hero hit by Sleeping Dart. Upon waking, enemy Heroes take 10% of their Maximum Health in damage.

Ana Mind-Numbing Agent ?
Mind-Numbing Agent (Level 7) Ana

Every Dose a Hero has reduces their Spell Power by 10%.



Anti-Healer Icon Anti-Healer provides a bit more uptime on the healing reduction by itself and slightly more healing and self-sustain when combined with Contact Healing Icon Contact Healing at Level 1. The increased healing reduction duration is not really needed because a well-timed Biotic Grenade lasts enough to deny the most powerful healing Abilities used on the focused enemy Hero by themselves or their team.

Night Terrors Icon Night Terrors provides both a fair amount of mobility, something that Ana lacks, and a high amount of burst damage, something that is really strong once you realize that the healing reduction provided by Biotic Grenade Icon Biotic Grenade indirectly acts as burst damage. The bonus damage will trigger either when the Sleep lasts for its full duration or when it ends pre-emptively. The damage part is particularly effective on high-Health enemy Heroes, usually Tanks and Bruisers. The bonus Movement Speed is really good to save Ana from trouble when she has Shrike Icon Shrike active and cannot disable it yet due to the 4 seconds cooldown not allowing because it will basically make you move at normal Movement Speed 2 seconds earlier than usual.

Mind-Numbing Agent Icon Mind-Numbing Agent allows Ana to reduce both damage and healing coming from enemy Abilities used by the target of her Basic Attacks, usually the enemy Tank or Bruiser. Do not see this Talent as a counter to Mages because you cannot reliably use Basic Attacks on them.


Level 10 Talents for Ana

Ana Nano Boost
Nano Boost (Level 10) Ana
  • Mana: 60
  • Cooldown: 70 seconds

Instantly boost an allied Hero, restoring 200 Mana. For the next 8 seconds, they gain 30% Spell Power and their Basic Ability cooldowns recharge 150% faster.

Cannot be used on Ana.

Ana Eye of Horus ?
Eye of Horus (Level 10) Ana
  • Mana: 45
  • Cooldown: 60 seconds

Assume a sniping position, gaining the ability to fire up to 6 specialized rounds with unlimited range. Rounds pierce allied and enemy Heroes but collide with enemy Structures in their path. Allies are healed for 225 (+4% per level) and enemies are damaged for 135 (+4% per level). Deals 50% less damage to Structures.

Ana is unable to move while Eye of Horus is active.



Nano Boost Icon Nano Boost is the ultimate weapon when your team features one or several Mages in your roster (such as Kel'Thuzad or even Alarak) because of the Spell Power increase and it is still somewhat useful when you do not because of the cooldown reduction provided that many Heroes can benefit from.

Eye of Horus Icon Eye of Horus can be useful on Maps where it is crucial to win the solo lane and you want a tool to help with that. Avoid picking this Heroic Ability without a serious reason because it comes with three major drawbacks, all being a consequence of the stationary position: it makes Ana an easy target to hit; it might increase the distance between Ana and her allied Heroes when her team plays offensively; it might force her to cancel it to retreat when the enemy team is playing offensively.


Level 13 Talents for Ana

Ana Speed Serum
Speed Serum (Level 13) Ana

Healing Dart grants 25% Movement Speed to affected Heroes for 1 seconds.

Ana Purifying Darts ?
Purifying Darts (Level 13) Ana

Healing Dart removes Roots and Slows from the target, and heals for 20% more when doing so.

Ana Smelling Salts
Smelling Salts (Level 13) Ana

Healing Dart removes Stuns from the target, and grants them 50 Armor for 2 seconds when doing so.



Speed Serum Icon Speed Serum looks like the least situational Talent of this Tier because it does not require a specific condition, but in practice you will easily have a way to trigger the others in most if not all games. While it is not a big deal, you should know that the Movement Speed provided by this Talent can also potentially mess up your aim because the Movement Speed buff will expire exactly when the next Healing Dart Icon Healing Dart will come off cooldown.

Purifying Darts Icon Purifying Darts is a good Talent because Slows are really common and it also works against Roots. Pick this Talent when you cannot get enough value from Smelling Salts or when you really need to remove a Root to save allied Heroes from death (such as against Kel'Thuzad).

Smelling Salts Icon Smelling Salts is a strong Talent that gets massive value against burst compositions, teams whose main strategy is to Stun an enemy Hero and then follow-up with burst damage. Pick this Talent every time you play against at least 1 Stun to get value out of it.


Level 16 Talents for Ana

Ana Sharpshooter
Sharpshooter (Level 16) Ana

Healing Dart's healing is increased by 5% if it heals a Hero, up to 50%. This bonus is reset if Healing Dart fails to hit a Hero.

Ana Concentrated Doses
Concentrated Doses (Level 16) Ana

Increase Healing Dart's healing by 10% for each Dose active on enemy Heroes.

Ana Active Reload
Active Reload (Level 16) Ana

Activate to instantly gain 3 charges of Healing Dart.



Sharpshooter Icon Sharpshooter increases your already good sustained healing in and out of combat even more, yet it does not compete with the utility provided by Active Reload Icon Active Reload explained later on.

Concentrated Doses Icon Concentrated Doses increases your already good sustained healing in combat but not out of combat, yet it does not match the value given by Active Reload Icon Active Reload mentioned below.

Active Reload Icon Active Reload gives Ana a huge amount of burst healing when needed. It comes with a reasonable cooldown of 60 seconds, allowing Ana to have it available for every important team fight.


Level 20 Talents for Ana

Ana Nano Infusion
Nano Infusion (Level 20) Ana

Allies affected by Nano Boost heal for 50% of Spell Damage dealt.

Ana Deadeye ?
Deadeye (Level 20) Ana

Increase Eye Of Horus' healing and damage by 4% for every Hero hit. This bonus resets after all shots have been fired.

Ana Armored Stance ?
Armored Stance (Level 20) Ana

Increase Shrike's damage by 50%. While Aim Down Sights is active, gain 25 Armor.

Ana Dynamic Optics ?
Dynamic Optics (Level 20) Ana

Basic Attacks increase Attack Speed by 10% for 3 seconds, up to 100%. While Aim Down Sights is active, increase your Basic Attack Range by 4.



Nano Infusion Icon Nano Infusion is a good and straightforward Talent with no downsides. The additional healing it provides can help the target allied Hero to go for a more aggressive playstyle to deliver as many empowered Abilities as possible.

Deadeye Icon Deadeye is another straightforward Talent that provides good value. The additional damage and healing it gives can allow you to secure a kill or to save an allied Hero respectively. If the enemy team composition tends to play grouped, it will easily ramp up in value because hitting multiple Heroes with a single shot will count as a multiple hits.

Dynamic Optics Icon Dynamic Optics is the best offensive option you can pick in this Tier because it gives Ana more damage per second by increasing her Attack Speed, something that will increase her self-sustain thanks to Shrike Icon Shrike converting part of the damage to healing. You rarely need this Talent anyways.

Armored Stance Icon Armored Stance is the best defensive option you can pick in this Tier because it gives Ana more survivability in the form of Armor and self-sustain derived from the additional Shrike Icon Shrike's damage being partially converted to healing. All that said, you rarely need this Talent.



  • 22 Apr. 2020: Talent Build Cheatsheet updated to reflect the current metagame.
  • 31 Mar. 2020: Talent Build fully revised to match new standards.
    • Talent Build and Talent Build Cheatsheet modified to reflect the current metagame.
    • Talent Descriptions modified to better describe when to pick them.
  • 03 Jun. 2019: Changed Eye of Horus from Situational to Recommended and updated the talent builds accordingly.
  • 13 Feb. 2019: Updated Ana's talents and builds in accordance with the latest rework.
  • 07 Mar. 2018: Updated Ana's Talent Builds in accordance with the most recent balanced update.
  • 29 Jan. 2018: Overdose is now Recommended and Aim Down Sights is now Not Recommended as intended.
  • 13 Oct. 2017: Changed Dynamic Shooting from Not Recommended to Recommended and fixed Overdose's description.
  • 29 Sep. 2017: Updated talent builds and descriptions after further playtesting.
  • 28 Sep. 2017: Added talent discussions.
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